Female reproductive health impacts of Long COVID and associated illnesses including ME/CFS, POTS, and connective tissue disorders: a literature review.

Long COVID disproportionately affects premenopausal women, but relatively few studies have examined Long COVID's impact on female reproductive health. We conduct a review of the literature documenting the female reproductive health impacts of Long COVID which may include disruptions to the menstrual cycle, gonadal function, ovarian sufficiency, menopause, and fertility, as well as symptom exacerbation around menstruation. Given limited research, we also review the reproductive health impacts of overlapping and associated illnesses including myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), postural orthostatic tachycardia syndrome (POTS), connective tissue disorders like Ehlers-Danlos syndrome (EDS), and endometriosis, as these illnesses may help to elucidate reproductive health conditions in Long COVID. These associated illnesses, whose patients are 70%-80% women, have increased rates of dysmenorrhea, amenorrhea, oligomenorrhea, dyspareunia, endometriosis, infertility, vulvodynia, intermenstrual bleeding, ovarian cysts, uterine fibroids and bleeding, pelvic congestion syndrome, gynecological surgeries, and adverse pregnancy complications such as preeclampsia, maternal mortality, and premature birth. Additionally, in Long COVID and associated illnesses, symptoms can be impacted by the menstrual cycle, pregnancy, and menopause. We propose priorities for future research and reproductive healthcare in Long COVID based on a review of the literature. These include screening Long COVID patients for comorbid and associated conditions; studying the impacts of the menstrual cycle, pregnancy, and menopause on symptoms and illness progression; uncovering the role of sex differences and sex hormones in Long COVID and associated illnesses; and addressing historical research and healthcare inequities that have contributed to detrimental knowledge gaps for this patient population.

Different combinations of monensin and narasin on growth performance, carcass traits, and ruminal fermentation characteristics of finishing beef cattle.

The objective of this study was to evaluate the effects of different combinations of monensin and narasin on finishing cattle. In Exp. 1, 40 rumen-cannulated Nellore steers [initial body weight (BW) = 231 ± 3.64 kg] were blocked by initial BW and assigned to one of the five treatments as follows: Control (CON): no feed additive in the basal diet during the entire feeding period; Sodium monensin (MM) at 25 mg/kg dry matter (DM) during the entire feeding period [adaptation (days 1-21) and finishing (days 22-42) periods]; Narasin (NN) at 13 mg/kg DM during the entire feeding period (adaptation and finishing periods); Sodium monensin at 25 mg/kg DM during the adaptation period and narasin at 13 mg/kg DM during the finishing period (MN); and narasin at 13 mg/kg DM during the adaptation period and sodium monensin at 25 mg/kg DM during the finishing period (NM). Steers fed MM had lower dry matter intake (DMI) during the adaptation period compared to NM (P = 0.02) but not compared to CON, MM, MN, or NN (P ≥ 0.12). No differences in DMI were observed among the treatments during the finishing (P = 0.45) or the total feeding period (P = 0.15). Treatments did not affect the nutrient intake (P ≥ 0.51) or the total apparent digestibility of nutrients (P ≥ 0.22). In Exp. 2, 120 Nellore bulls (initial BW = 425 ± 5.4 kg) were used to evaluate the effects of the same treatments of Exp. 1 on growth performance and carcass characteristics of finishing feedlot cattle. Steers fed NM had greater DMI during the adaptation period compared to CON, MM, and MN (P ≤ 0.03), but no differences were observed between NM and NN (P = 0.66) or between CON, MM, and NN (P ≥ 0.11). No other differences between treatments were observed (P ≥ 12). Feeding narasin at 13 mg/kg DM during the adaptation period increases the DMI compared to monensin at 25 mg/kg DM, but the feed additives evaluated herein did not affect the total tract apparent digestibility of nutrients, growth performance, or carcass characteristics of finishing cattle.

Residual effect of narasin on feed intake and rumen fermentation characteristics in Nellore steers fed forage-based diet.

This study aimed to evaluate the residual effect of narasin on intake and ruminal fermentation parameters in Nellore cattle fed a forage-based diet. Thirty rumen-cannulated Nellore steers [initial body weight (BW) = 281 ± 21 kg] were allocated to individual pens in a randomized complete block design, with 10 blocks and 3 treatments, defined according to the fasting BW at the beginning of the experiment. The animals were fed a forage-based diet containing 99% Tifton-85 haylage and 1% concentrate. Within blocks, animals were randomly assigned to one of three treatments: (1) forage-based diet without addition of narasin (CON; n = 10), (2) CON diet plus 13 mg of narasin/kg DM (N13; n = 10), or (3) CON diet plus 20 mg of narasin/kg DM (N20; n =10). The experiment lasted 156 d and was divided into two periods. The first period lasted 140 d and consisted of the daily supply of narasin. In the second period (last 16 d), the animals were not supplemented with narasin when the residual effect of the additive was evaluated. The treatments were evaluated by linear and quadratic orthogonal contrasts. The results were reported as least square means and the effect was considered significant when P ≤ 0.05. No treatment × day interaction was identified for dry matter intake (P = 0.27). There was a treatment × day (P ≤ 0.03) interaction after narasin removal for the molar proportion of acetate, propionate, ac:prop ratio, and ammonia nitrogen. The inclusion of narasin decreased linearly (P < 0.01) the molar proportion of acetate (P < 0.01), and this effect persisted until day 5 after narasin withdrawal (P < 0.01). Narasin inclusion linearly increased the molar proportion of propionate (P < 0.04), and linearly decreased (P < 0.01) ac:prop ratio up to 5 d after removing narasin from the diets. No treatment effects were observed (P > 0.45) on days 8 and 16 after the withdrawal. Narasin linearly decreased ammonia nitrogen up to 1 day after withdrawal (P < 0.01). In conclusion, the use of narasin for a prolonged period (140 d) resulted in a residual effect on rumen fermentation parameters after the removal of the additive from the diets.

Occurrence of Sex Chromosomes in Fish of the Genus Ancistrus with a New Description of Multiple Sex Chromosomes in the Ecuadorian Endemic Ancistrus clementinae (Loricariidae).

Ancistrus Kner, 1854, is the most diverse genus among the Ancistrini (Loricariidae) with 70 valid species showing a wide geographic distribution and great taxonomic and systematic complexity. To date, about 40 Ancistrus taxa have been karyotyped, all from Brazil and Argentina, but the statistic is uncertain because 30 of these reports deal with samples that have not yet been identified at the species level. This study provides the first cytogenetic description of the bristlenose catfish, Ancistrus clementinae Rendahl, 1937, a species endemic to Ecuador, aiming to verify whether a sex chromosome system is identifiable in the species and, if so, which, and if its differentiation is associated with the presence of repetitive sequences reported for other species of the family. We associated the karyotype analysis with the COI molecular identification of the specimens. Karyotype analysis suggested the presence of a ♂ZZ/♀ZW1W2 sex chromosome system, never detected before in Ancistrus, with both W1W2 chromosomes enriched with heterochromatic blocks and 18S rDNA, in addition to GC-rich repeats (W2). No differences were observed between males and females in the distribution of 5S rDNA or telomeric repeats. Cytogenetic data here obtained confirm the huge karyotype diversity of Ancistrus, both in chromosome number and sex-determination systems.

Drug-drug interactions of immunosuppressants and other drugs in kidney post-transplant recipients

Introduction: Immunosuppressants (ISS) are the most crucial tools used in the therapeutic regimens of transplant recipients. Nevertheless, these drugs are not the only ones adopted by patients; therefore, knowing the possible drug-drug interactions (DDIs) between immunosuppressants and other drugs commonly used in kidney transplant recipients is essential to ensure the effectiveness and safety of treatments. In this way, the objective is analyzing the DDIs between the immunosuppressants and other commonly used medications on kidney transplant adult recipients with active medical records undergoing post-transplant follow-up for 4.4 years (mean). Methods: First, we performed a cross-sectional study based on patients' records, in which the patient's profile and drugs used were examined, and after we analyzed DDIs by the Micromedex Drug Interactions® database. Results: We analyzed 176 patients with a mean age of 47.6(± 12.5); most were male (67.7%), and the majority received a kidney from a deceased donor (81.4%). Patients were exposed to 15.0 (± 5.4) different medicines after the transplantation, and 7.4 (± 4.0) of these medicines were simultaneous. After analyzing the DDIs according to the severity of interaction, documentation quality interaction effect, clinical management and probable interaction mechanism, the most frequent interaction was with tacrolimus, classified as moderate, and the 3 major causes of interaction occurred with azathioprine according to the Micromedex database. The primary medicines involved with immunosuppressant interactions were proton pump inhibitors, ranitidine, domperidone, amlodipine, enalapril, allopurinol, cyclobenzaprine, amitriptyline, fluoxetine, and ciprofloxacin. These DDIs' effects were related to, mainly, increase their immunosuppressant activity. Conclusion: Although the immunosuppressants analyzed lacked many clinical DDIs significance with other medicines, the healthcare team needs to monitor their DDIs' effects to prevent and minimize side effects in transplanted recipients.

Low back pain and joint position changes in cyclists: a cross-sectional study / Dolor lumbar y cambios en la posición de las articulaciones en ciclistas: un estudio transversal / Dor lombar e alterações do posicionamento articular em ciclistas: um estudo transversal

ABSTRACT Introduction: Low back pain is one of the most common complaints among cyclists. The disharmony of the cyclist-bike combination may be a predisposing factor. Bike Fit is a technique that aims to adjust the bike to the individual characteristics of the cyclist. Objectives: To investigate the relationship between the cyclist's position on the bicycle and the occurrence of complaints of low back pain. Methods: Data obtained during Bike Fit from 62 amateur cyclists were used in the study. Cyclists were filmed during the act of pedaling on a stationary roller and image analysis was performed using Kinovea® software. Data related to complaints of low back pain and positioning on the bicycle were used in the Chi-Square test and binary logistic regression. Results: The mean age was 38.06 ± 8.82 years, 87.7% of the sample was composed of men and low back pain was found in 40.3% (25/62) of the participants. Univariate analysis showed a positive correlation between low back pain and the following variables: ankle dorsiflexion angle (X2=6.947, p=0.014) and upper limb reach (X2=5.247; p=0.032). Binary logistic regression showed a positive association between reaching with the upper limbs and low back pain (r=2.728; p=0.002) and a negative association between knee advancement and low back pain (r= -2.281; p=0.007). Conclusion: Cyclists with low back pain present changes in their position on the bicycle, which reinforces the importance of evaluating the cyclist/bike combination. However, it is not possible to state whether the positional changes observed in the study sample are causes or consequences of low back pain. Level of evidence: Level III; Cross-sectional observational study.

RESUMEN Introducción: El dolor lumbar es una de las quejas más frecuentes en los practicantes de ciclismo. Puede tener como factor predisponente la falta de armonía del conjunto ciclista-bicicleta. Bike Fit es una técnica que tiene como objetivo ajustar la bicicleta a las características individuales del ciclista. Objetivos: Investigar la relación entre la posición del ciclista en la bicicleta y la aparición de quejas de lumbalgia. Métodos: En el estudio se utilizaron datos obtenidos durante el Bike Fit de 62 ciclistas aficionados. Los ciclistas fueron filmados durante el acto de pedalear sobre un rodillo estacionario y el análisis de las imágenes se realizó utilizando el software Kinovea®. Los datos relacionados con las quejas de dolor lumbar y la posición en la bicicleta se utilizaron en la prueba de Chi-Cuadrado y regresión logística binaria. Resultados: La edad media fue de 38,06 ± 8.82 años, el 87,7% de la muestra estuvo compuesta por hombres y se constató dolor lumbar en el 40,3% (25/62) de los participantes. El análisis univariado mostró una correlación positiva entre el dolor lumbar y las siguientes variables: ángulo de dorsiflexión del tobillo (X2 = 6,947, p = 0,014) y alcance de las extremidades superiores (X2 = 5,247; p = 0,032). La regresión logística binaria mostró una asociación positiva entre el alcance de las extremidades superiores y el dolor lumbar (r = 2,728; p = 0,002) y una asociación negativa para el avance de la rodilla y el dolor lumbar (r = -2,281; p = 0,007). Conclusiones: Los ciclistas con dolor lumbar presentan cambios en su posición sobre la bicicleta, lo que refuerza la importancia de la evaluación del conjunto ciclista-bicicleta. Sin embargo, no es posible afirmar si los cambios posicionales observados en la muestra estudiada son causas o consecuencias del dolor lumbar. Nivel de evidencia: Nivel III; Estudio observacional transversal.

RESUMO Introdução: A dor lombar é uma das queixas mais comuns nos praticantes de ciclismo. Pode ter como fator predisponente a desarmonia do conjunto ciclista-bicicleta. O Bike Fit é uma técnica que visa ajustar a bicicleta às características individuais do ciclista. Objetivos: Investigar a relação entre o posicionamento do ciclista na bicicleta e a ocorrência de queixas de dor lombar. Métodos: Os dados obtidos durante o Bike Fit de 62 ciclistas amadores foram utilizados no estudo. Os ciclistas foram filmados durante a pedalada em um rolo estacionário e a análise das imagens foi realizada pelo software Kinovea®. Os dados relacionados com a queixa de dor lombar e ao posicionamento na bicicleta foram utilizados no teste do Qui-quadrado e de regressão logística binária. Resultados: A média de idade foi de 38,06 ± 8,82 anos, 87,7% da amostra foi composta por homens e a dor lombar foi constatada em 40,3% (25/62) dos participantes. A análise univariada mostrou correlação positiva entre a dor lombar e as seguintes variáveis: ângulo de dorsiflexão do tornozelo (X2 = 6,947, p = 0,014) e alcance dos membros superiores (X2 = 5,247; p = 0,032). A regressão logística binária mostrou uma associação positiva entre alcance dos membros superiores e dor lombar (r = 2,728; p = 0,002) e associação negativa para avanço dos joelhos e dor lombar (r = -2,281; p = 0,007). Conclusão: Os ciclistas com dor lombar apresentam alterações de posicionamento na bicicleta, o que reforça a importância da avaliação do conjunto ciclista-bicicleta. Entretanto, não é possível afirmar se as alterações de posicionamento observadas na amostra estudada são causas ou consequências da dor lombar. Nível de evidência: Nível III; Estudo observacional transversal.

Vivências de cuidadores de crianças com paralisia cerebral sobre a utilização de gastrostomia / Experiences of caregivers of children with cerebral palsy on the use of gastrostomy / Experiencias de cuidadores de niños con parálisis cerebral sobre el uso de gastrostomía

Objetivo: compreender as necessidades de cuidadores de crianças com paralisia cerebral que fazem uso de gastrostomia. Método: estudo descritivo de abordagem qualitativa, realizado na Unidade Escola de Enfermagem da Universidade Estadual do Centro-Oeste, em Guarapuava- Paraná. Os dados foram coletados mediante entrevista e analisados através da técnica de análise de conteúdo. Resultados: Participaram do estudo três cuidadoras, com média de idade de 30,6 anos, a maioria casadas, todas com ensino médio completo e do lar. A partir das entrevistas foram levantadas três categorias: processo de adaptação familiar e as dificuldades ao uso da gastrostomia; necessidades relacionadas aos cuidados com a gastrostomia e a importância do cuidado multidisciplinar. Conclusão: O estudo mostrou que as cuidadoras apresentaram medo em relação ao cuidado com a gastrostomia e reconhecem a necessidade de apoio da equipe multiprofissional. O papel do enfermeiro é fundamental nesse contexto, melhorando a aceitação e fornecendo orientações quanto aos cuidados domiciliares (AU).

Objective: to understand the needs of caregivers of children with cerebral palsy who use gastrostomy. Method: descriptive study with a qualitative approach, carried out at the School of Nursing Unit of the State University of the Midwest, in Guarapuava-Paraná. Data were collected through interviews and analyzed using the content analysis technique. Results: Three caregivers participated in the study, with a mean age of 30.6 years, most of them married, all of them with high school education and housework. From the interviews, three categories were raised: family adaptation process and difficulties in using the gastrostomy; needs related to gastrostomy care and the importance of multidisciplinary care. Conclusion: The study showed that caregivers were afraid of gastrostomy care and recognized the need for support from the multidisciplinary team. The nurse's role is fundamental in this context, improving acceptance and providing guidance on home care (AU).

Objetivo: comprender las necesidades de los cuidadores de niños con parálisis cerebral que utilizan gastrostomía. Método: estudio descriptivo con abordaje cualitativo, realizado en la Unidad Escuela de Enfermería de la Universidad Estadual del Medio Oeste, en Guarapuava- Paraná. Los datos fueron recolectados a través de entrevistas y analizados utilizando la técnica de análisis de contenido. Resultados: Participaron del estudio tres cuidadores, con una media de edad de 30,6 años, la mayoría casados, todos con estudios secundarios y labores domésticas. De las entrevistas surgieron tres categorías: proceso de adaptación familiar y dificultades en el uso de la gastrostomía; necesidades relacionadas con el cuidado de la gastrostomía y la importancia del cuidado multidisciplinario. Conclusión: El estudio mostró que los cuidadores tenían miedo al cuidado de la gastrostomía y reconocieron la necesidad de apoyo del equipo multidisciplinario. El papel del enfermero es fundamental en este contexto, mejorando la aceptación y orientando en el cuidado domiciliario (AU).

Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus.

According to the World Health Organization (WHO), in the second half of 2022, there are about 606 million confirmed cases of COVID-19 and almost 6,500,000 deaths around the world. A pandemic was declared by the WHO in March 2020 when the new coronavirus spread around the world. The short time between the first cases in Wuhan and the declaration of a pandemic initiated the search for ways to stop the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or to attempt to cure the disease COVID-19. More than ever, research groups are developing vaccines, drugs, and immunobiological compounds, and they are even trying to repurpose drugs in an increasing number of clinical trials. There are great expectations regarding the vaccine's effectiveness for the prevention of COVID-19. However, producing sufficient doses of vaccines for the entire population and SARS-CoV-2 variants are challenges for pharmaceutical industries. On the contrary, efforts have been made to create different vaccines with different approaches so that they can be used by the entire population. Here, we summarize about 8162 clinical trials, showing a greater number of drug clinical trials in Europe and the United States and less clinical trials in low-income countries. Promising results about the use of new drugs and drug repositioning, monoclonal antibodies, convalescent plasma, and mesenchymal stem cells to control viral infection/replication or the hyper-inflammatory response to the new coronavirus bring hope to treat the disease.

O isolamento social para prevenção da Covid-19 pode aumentar o risco de queimaduras no domicílio / Social isolation for prevention of Covid-19 may increase the risk of Burns at household

Resumo Introdução Durante a pandemia de Covid-19, o uso do álcool a 70° GL foi amplamente recomendado para a higienização das mãos e superfícies. Acoplada à maior permanência das pessoas dentro do domicílio, essa recomendação pode contribuir para o aumento do risco de queimaduras. Objetivo Delinear os riscos de queimaduras no contexto da pandemia. Método Revisão por meio de análise documental. Resultados O álcool líquido 70° GL e o álcool isopropílico 70° GL são substâncias que apresentam maior risco de ignição no uso e armazenamento. O álcool 70° GL em gel deve ser priorizado tanto pela maior facilidade de uso para antissepsia das mãos como pelo menor risco de inflamabilidade. Esses materiais não devem ser manuseados durante o preparo de alimentos. Conclusão As autoridades sanitárias e governamentais devem se responsabilizar pela divulgação dos cuidados necessários para prevenção de queimaduras e incêndios no contexto da pandemia.

Abstract Background During the Covid-19 pandemic, the use of alcohol at 70° GL was widely recommended for hand and surface hygiene. Combined with greater permanency of individuals in the household, this recommendation may contribute to an increased risk of burns. Objective To outline the risks of burns in the context of the pandemic. Method A review through document analysis was carried out. Results Liquid alcohol 70° GL and isopropyl alcohol 70° GL are substances that present a greater risk of ignition during use and storage. Alcohol 70° GL in gel should be prioritized both for its greater easier of use for hand antisepsis and for its lower risk of flammability. These materials must not be handled during food preparation. Conclusion Health and government authorities must be responsible for disseminating the necessary care to prevent burns and fires in the context of the pandemic.

Haemosporidian parasites and incubation period influence plumage coloration in tanagers (Passeriformes: Thraupidae).

Birds are highly visually oriented and use plumage coloration as an important signalling trait in social communication. Hence, males and females may have different patterns of plumage coloration, a phenomenon known as sexual dichromatism. Because males tend to have more complex plumages, sexual dichromatism is usually attributed to female choice. However, plumage coloration is partly condition-dependent; therefore, other selective pressures affecting individuals' success may also drive the evolution of this trait. Here, we used tanagers as model organisms to study the relationships between dichromatism and plumage coloration complexity in tanagers with parasitism by haemosporidians, investment in reproduction and life-history traits. We screened blood samples from 2849 individual birds belonging to 52 tanager species to detect haemosporidian parasites. We used publicly available data for plumage coloration, bird phylogeny and life-history traits to run phylogenetic generalized least-square models of plumage dichromatism and complexity in male and female tanagers. We found that plumage dichromatism was more pronounced in bird species with a higher prevalence of haemosporidian parasites. Lastly, high plumage coloration complexity in female tanagers was associated with a longer incubation period. Our results indicate an association between haemosporidian parasites and plumage coloration suggesting that parasites impact mechanisms of sexual selection, increasing differences between the sexes, and social (non-sexual) selection, driving females to develop more complex coloration.

Host life-history traits predict haemosporidian parasite prevalence in tanagers (Aves: Thraupidae).

Vector-borne parasites are important ecological drivers influencing life-history evolution in birds by increasing host mortality or susceptibility to new diseases. Therefore, understanding why vulnerability to infection varies within a host clade is a crucial task for conservation biology and for understanding macroecological life-history patterns. Here, we studied the relationship of avian life-history traits and climate on the prevalence of Plasmodium and Parahaemoproteus parasites. We sampled 3569 individual birds belonging to 53 species of the family Thraupidae. Individuals were captured from 2007 to 2018 at 92 locations. We created 2 phylogenetic generalized least-squares models with Plasmodium and Parahaemoproteus prevalence as our response variables, and with the following predictor variables: climate PC1, climate PC2, body size, mixed-species flock participation, incubation period, migration, nest height, foraging height, forest cover, and diet. We found that Parahaemoproteus and Plasmodium prevalence was higher in species inhabiting open habitats. Tanager species with longer incubation periods had higher Parahaemoproteus prevalence as well, and we hypothesize that these longer incubation periods overlap with maximum vector abundances, resulting in a higher probability of infection among adult hosts during their incubation period and among chicks. Lastly, we found that Plasmodium prevalence was higher in species without migratory behaviour, with mixed-species flock participation, and with an omnivorous or animal-derived diet. We discuss the consequences of higher infection prevalence in relation to life-history traits in tanagers.

Trauma em ambientes rurais: avaliação de pacientes internados em unidade de terapia intensiva / Trauma in rural environments: evaluation of patients interned in intensive care unit / Traumatismos en entornos rurales: evaluación de los pacientes ingresados en una unidad de cuidados intensivos

O acesso limitado do atendimento ao trauma aumenta proporcionalmente à ruralidade, refletindo em uma maior mortalidade e invalidez a longo prazo. A pesquisa objetivou identificar os desfechos de pacientes internados por trauma em Unidades de Terapia Intensiva, acometidos em ambientes rurais. Trata-se de um estudo transversal observacional realizado em uma UTI geral de um hospital da região central do Estado do Paraná entre 2013 a 2019, através da análise de prontuários de 230 pacientes traumatizados em ambiente rural. Os dados foram analisados por meio de testes de Qui-quadrado de Pearson, exato de Fisher ou t de Student. Dentre os desfechos identificados, observou-se associação do sexo feminino com as comorbidades (p=0,024), das regiões mais afetadas de cabeça, pescoço e tórax com a gravidade do trauma (p=0,001), além de variáveis do primeiro atendimento, como suporte respiratório básico, PAS <90mmHg e Glasgow associados à pacientes cirúgicos e pupilas alteradas em pacientes clínicos. Para o desfecho, observou-se que as médias do tempo de permanência hospitalar foi significativamente menor para aqueles que foram a óbito. As características apresentadas assemelham-se às informações mencionadas na literatura, em que as lesões graves com a necessidade de intervenção cirúrgica e maior tempo de permanência hospitalar estão associados ao óbito em traumas rurais. Contudo, o trauma no ambiente rural, apesar de não refletir nem sempre em maior gravidade, apresenta desfechos impactantes para o paciente.

Limited access to trauma care increases proportionally to rurality, reflecting higher mortality and long-term disability. The research aimed to identify the outcomes of patients hospitalized for trauma in Intensive Care Units, affected in rural environments. This is an observational cross-sectional study carried out in a general ICU of a hospital in the central region of the State of Paraná between 2013 and 2019, through the analysis of medical records of 230 trauma patients in a rural environment. Data were analyzed using Pearson's chi-square, Fisher's exact or Student's t tests. Among the outcomes identified, there was an association between female sex and comorbidities (p=0.024), the most affected regions of the head, neck and chest with the severity of the trauma (p=0.001), in addition to variables of the first care, such as basic respiratory support, SBP <90mmHg and Glasgow associated with surgical patients and altered pupils in medical patients. For the outcome, it was observed that the average length of hospital stay was significantly lower for those who died. The characteristics presented are similar to the information mentioned in the literature, in which serious injuries requiring surgical intervention and longer hospital stays are associated with death in rural traumas. However, trauma in the rural environment, although not always reflecting greater severity, has impacting outcomes for the patient.

El acceso limitado a la atención traumatológica aumenta proporcionalmente a la ruralidad, lo que se refleja en una mayor mortalidad y discapacidad a largo plazo. La investigación tenía como objetivo identificar los resultados de los pacientes ingresados por traumatismos en las Unidades de Cuidados Intensivos, afectados en entornos rurales. Se trata de un estudio observacional transversal realizado en una UCI general de un hospital de la región central del Estado de Paraná entre 2013 y 2019, a través del análisis de las historias clínicas de 230 pacientes lesionados en el medio rural. Los datos se analizaron mediante las pruebas de chi-cuadrado de Pearson, exacta de Fisher o t de Student. Entre los resultados identificados, el sexo femenino se asoció con las comorbilidades (p=0,024), las regiones más afectadas de la cabeza, el cuello y el tórax con la gravedad del traumatismo (p=0,001), además de las variables de los primeros cuidados, como la asistencia respiratoria básica, la PAS <90mmHg y el Glasgow asociado a los pacientes quirúrgicos y las pupilas alteradas en los pacientes clínicos. En cuanto al resultado, se observó que la duración media de la estancia hospitalaria fue significativamente menor para los que murieron. Las características presentadas son similares a la información mencionada en la literatura, en la que las lesiones graves con necesidad de intervención quirúrgica y mayor estancia hospitalaria se asocian a la muerte en el trauma rural. Sin embargo, el traumatismo en el medio rural, a pesar de no reflejar siempre una mayor gravedad, presenta resultados impactantes para el paciente.

B Chromosomes in Psalidodon scabripinnis (Characiformes, Characidae) Species Complex.

B chromosomes are extra-genomic components of cells found in individuals and in populations of some eukaryotic organisms. They have been described since the first observations of chromosomes, but several aspects of their biology remain enigmatic. Despite being present in hundreds of fungi, plants, and animal species, only a small number of B chromosomes have been investigated through high-throughput analyses, revealing the remarkable mechanisms employed by these elements to ensure their maintenance. Populations of the Psalidodon scabripinnis species complex exhibit great B chromosome diversity, making them a useful material for various analyses. In recent years, important aspects of their biology have been revealed. Here, we review these studies presenting a comprehensive view of the B chromosomes in the P. scabripinnis complex and a new hypothesis regarding the role of the B chromosome in the speciation process.

Transplante de células-tronco hematopoiéticas: iniquidades na distribuição em território brasileiro, 2001 a 2020 / Hematopoietic stem-cell transplants in Brazil: inequities in the distribution in Brazilian territory, 2001 to 2020

Resumo O objetivo deste artigo é descrever a distribuição de Centros Transplantadores (CTs) e transplantes de células-tronco hematopoiéticas (TCTH) no território brasileiro. Estudo descritivo, que reúne informações sobre a distribuição CTs e o número de procedimentos realizados entre 2001 e 2020, a partir das fontes dos dados: Sociedade Brasileira de Terapia celular e Transplantes de Medula Óssea (SBTMO); Associação Brasileira de Transplante de Órgãos (ABTO); Sistema de Informações Hospitalares do Sistema Único de Saúde (SIH/SUS); e Ministério da Saúde (MS). Foram identificados 86 CTs, com predominância na região Sudeste do país (64%). A região Norte não possui CTs. No período contabilizaram-se mais de 30 mil procedimentos, concentrados nas regiões Sudeste e Sul. O TCTH do tipo alogênico foi prevalente. Constataram-se divergências entre os números de transplantes realizados a depender da fonte consultada. Apesar do crescimento do número de procedimentos no período do estudo, tanto a distribuição de CTs quanto o número de TCTHs se concentrou em regiões mais desenvolvidas. Essa heterogeneidade pode ter propiciado iniquidades no acesso ao tratamento pela população.

Abstract The scope of this article is to describe the distribution of Transplant Centers (TCs) and hematopoietic stem-cell transplants (HSCTs) in the Brazilian territory. It is a descriptive study, which brings together information on the distribution of TCs and the number of procedures performed between 2001 and 2020, based on the following data sources: the Brazilian Cell Therapy and Bone Marrow Transplant Society of (SBTMO); the Brazilian Organ Transplant Association (ABTO); the Hospital Information System of the Unified Health System (SIH/SUS); and the Ministry of Health (MS). A total of 86 TCs were identified, predominantly in the Southeastern region of the country (64%). There are no TCs in the Northern region. Throughout the period, there were more than 30,000 procedures, concentrated in the Southeastern and Southern regions. The allogeneic type of HSCT was prevalent. Differences were found between the numbers of transplants performed depending on the source consulted. Despite the increase in the number of procedures during the period studied, both the distribution of TCs and the number of HSCTs were concentrated in more developed regions. This heterogeneity may have led to inequities in the access of the population to treatment.

[Hematopoietic stem-cell transplants in Brazil: inequities in the distribution in Brazilian territory, 2001 to 2020]. / Transplante de células-tronco hematopoiéticas: iniquidades na distribuição em território brasileiro, 2001 a 2020.

The scope of this article is to describe the distribution of Transplant Centers (TCs) and hematopoietic stem-cell transplants (HSCTs) in the Brazilian territory. It is a descriptive study, which brings together information on the distribution of TCs and the number of procedures performed between 2001 and 2020, based on the following data sources: the Brazilian Cell Therapy and Bone Marrow Transplant Society of (SBTMO); the Brazilian Organ Transplant Association (ABTO); the Hospital Information System of the Unified Health System (SIH/SUS); and the Ministry of Health (MS). A total of 86 TCs were identified, predominantly in the Southeastern region of the country (64%). There are no TCs in the Northern region. Throughout the period, there were more than 30,000 procedures, concentrated in the Southeastern and Southern regions. The allogeneic type of HSCT was prevalent. Differences were found between the numbers of transplants performed depending on the source consulted. Despite the increase in the number of procedures during the period studied, both the distribution of TCs and the number of HSCTs were concentrated in more developed regions. This heterogeneity may have led to inequities in the access of the population to treatment.

O objetivo deste artigo é descrever a distribuição de Centros Transplantadores (CTs) e transplantes de células-tronco hematopoiéticas (TCTH) no território brasileiro. Estudo descritivo, que reúne informações sobre a distribuição CTs e o número de procedimentos realizados entre 2001 e 2020, a partir das fontes dos dados: Sociedade Brasileira de Terapia celular e Transplantes de Medula Óssea (SBTMO); Associação Brasileira de Transplante de Órgãos (ABTO); Sistema de Informações Hospitalares do Sistema Único de Saúde (SIH/SUS); e Ministério da Saúde (MS). Foram identificados 86 CTs, com predominância na região Sudeste do país (64%). A região Norte não possui CTs. No período contabilizaram-se mais de 30 mil procedimentos, concentrados nas regiões Sudeste e Sul. O TCTH do tipo alogênico foi prevalente. Constataram-se divergências entre os números de transplantes realizados a depender da fonte consultada. Apesar do crescimento do número de procedimentos no período do estudo, tanto a distribuição de CTs quanto o número de TCTHs se concentrou em regiões mais desenvolvidas. Essa heterogeneidade pode ter propiciado iniquidades no acesso ao tratamento pela população.

Epitope identification of SARS-CoV-2 structural proteins using in silico approaches to obtain a conserved rational immunogenic peptide.

The short time between the first cases of COVID-19 and the declaration of a pandemic initiated the search for ways to stop the spread of SARS-CoV-2. There are great expectations regarding the development of effective vaccines that protect against all variants, and in the search for it, we hypothesized the obtention of a predicted rational immunogenic peptide from structural components of SARS-CoV-2 might help the vaccine research direction. In the search for a candidate of an immunogenic peptide of the SARS-CoV-2 envelope (E), membrane (M), nucleocapsid (N), or spike (S) proteins, we access the predicted sequences of each protein after the genome sequenced worldwide. We obtained the consensus amino acid sequences of about 14,441 sequences of each protein of each continent and the worldwide consensus sequence. For epitope identification and characterization from each consensus structural protein related to MHC-I or MHC-II interaction and B-cell receptor recognition, we used the IEDB reaching 68 epitopes to E, 174 to M, 245 to N, and 833 to S proteins. To select an epitope with the highest probability of binding to the MHC or BCR, all epitopes of each consensus sequence were aligned. The curation indicated 1, 4, 8, and 21 selected epitopes for E, M, N, and S proteins, respectively. Those epitopes were tested in silico for antigenicity obtaining 16 antigenic epitopes. Physicochemical properties and allergenicity evaluation of the obtained epitopes were done. Ranking the results, we obtained one epitope of each protein except for the S protein that presented two epitopes after the selection. To check the 3D position of each selected epitope in the protein structure, we used molecular homology modeling. Afterward, each selected epitope was evaluated by molecular docking to reference MHC-I or MHC-II allelic protein sequences. Taken together, the results obtained in this study showed a rational search for a putative immunogenic peptide of SARS-CoV-2 structural proteins that can improve vaccine development using in silico approaches. The epitopes selected represent the most conserved sequence of new coronavirus and may be used in a variety of vaccine development strategies since they are also presented in the described variants of SARS-CoV-2.

[Longitudinal care: factors associated with adherence to postpartum follow-up according to data from PMAQ-AB]. / Longitudinalidade do cuidado: fatores associados à adesão à consulta puerperal segundo dados do PMAQ-AB.

The aim was to identify factors of longitudinal care associated with women´s adherence to postpartum consultation in Brazil. This was a cross-sectional study of data from 19,177 postpartum women who participated in the external assessment of the third cycle of the Brazilian National Program for Improvement of Access and Quality of Basic Care (PMAQ-AB), 2017. The dependent variable was postpartum consultation, and the independent variables, grouped hierarchically, were sociodemographic and economic at the distal level and issues analogous to longitudinal care at the proximal level. Multiple logistic regression analysis was performed with hierarchical entry of variables, where sociodemographic and economic variables were used to adjust the model. The results showed that 53% of women had undergone postpartum follow-up. The odds of adherence to postpartum follow-up were higher in women who received a home visit by a community health agents in the first week after childbirth (OR = 4.81), those with seven or more prenatal consultations (OR = 2.74), those who had sought care at the health unit in question (OR = 1.21), and those who had been seen by the same physician (OR = 1.14). In conclusion, the proportion of postpartum consultations was low (53%), and adherence to postpartum follow-up was higher when women received visits by community health agents, were accompanied by the same physician, had regular prenatal care, and had a specific healthcare unit as their regular source of care. Consistent longitudinal care was identified as an attribute of primary care that should be strengthened to improve postpartum care.

Objetivou-se identificar os fatores de longitudinalidade do cuidado associados à adesão das mulheres à consulta puerperal no Brasil. Trata-se de um estudo transversal com dados secundários de 19.177 puérperas que participaram da avaliação externa do terceiro ciclo do Programa Nacional de Melhoria do Acesso e da Qualidade da Atenção Básica (PMAQ-AB), de 2017. A variável dependente foi a realização de consulta puerperal e as variáveis independentes, agrupadas em níveis de maneira hierarquizada, foram as sociodemográficas e econômicas, como nível distal; e questões análogas à longitudinalidade do cuidado, como o nível proximal. Realizou-se análise de regressão logística múltipla, com entrada hierarquizada das variáveis, sendo as variáveis sociodemográficas e econômicas utilizadas para ajuste do modelo. Os resultados mostraram que a proporção de mulheres que realizaram consulta puerperal foi de 53%. Mulheres que receberam visita domiciliar do agente comunitário de saúde (ACS) na primeira semana após o parto (OR = 4,81), com sete ou mais consultas de pré-natal (OR = 2,74), que procuraram atendimento na unidade de saúde em questão (OR = 1,21) e atendidas pelo mesmo(a) médico(a) (OR = 1,14) têm mais chance de aderir à consulta puerperal. Conclui-se que a proporção de realização da consulta puerperal é baixa (53%), e que a adesão das mulheres à consulta puerperal é maior quando recebem visita do ACS, são acompanhadas pelo(a) mesmo(a) médico(a), têm acompanhamento pré-natal e têm uma unidade de saúde como fonte regular de cuidado. A longitudinalidade do cuidado foi identificada como um atributo da atenção primária que deve ser fortalecido para aprimorar a atenção pós-parto.

El objetivo fue identificar factores de longitudinalidad del cuidado asociados a la adhesión de las mujeres a la consulta posparto en Brasil. Se trata de un estudio transversal con datos secundarios de 19.177 puérperas que participaron en la evaluación externa del tercer ciclo del Programa Nacional de Mejoría de Acceso y Calidad de la Atención Básica (PMAQ-AB), 2017. La variable dependiente fue la realización de la consulta posparto y las variables independientes, agrupadas en niveles de manera jerarquizada, fueron las sociodemográficas y económicas, como nivel distal; cuestiones análogas a la longitudinalidad del cuidado, como nivel proximal. Se realizó un análisis de regresión logística múltiple, con entrada jerarquizada de las variables, siendo las variables sociodemográficas y económicas utilizadas para el ajuste del modelo. Los resultados mostraron que la proporción de mujeres que realizaron la consulta posparto fue de un 53%. Las mujeres que recibieron visita domiciliaria del agentes comunitarios de salud durante la primera semana tras el parto (OR = 4,81), con siete o más consultas prenatales (OR = 2,74), buscaron atención en la unidad de salud en cuestión (OR = 1,21) y fueron atendidas por el mismo(a) médico(a) (OR = 1,14) tienen más oportunidades de adherirse a la consulta posparto. Se concluye que la proporción de realización de la consulta posparto es baja (53%), y que la adhesión de las mujeres a la consulta puerperal es mayor cuando reciben visita del agentes comunitarios de salud, están acompañadas por el(a) mismo(a) médico(a), hay seguimiento prenatal y hay una unidad de salud como fuente de cuidado regular. La longitudinalidad del cuidado se identificó como un atributo de la atención primaria que debe ser fortalecido para perfeccionar la atención posparto.

Prevalence and factors associated with chronic critical disease in hospitalized for trauma in intensive care / Prevalencia y factores asociados a enfermedad crónica crítica en hospitalizados por trauma en cuidados intensivos / Prevalência e fatores associados à doença crítica crônica em hospitalizados por trauma em terapia intensiva

ABSTRACT Objective to identify the prevalence of chronic critical disease and associated factors in patients hospitalized for trauma in the Intensive Care Unit. Method case-control study, with data from medical records of adults hospitalized for trauma in an Intensive Care Unit, between 2013 and 2019. Data were collected from the patient admission book, the electroni cmedical records and the records of the Hospital Infection Control Service. The dependent variable was the occurrence of chronic critical disease, and the independent variables were related to sociodemographic characteristics, comorbidities, trauma, pre-hospital care, prognostic indices, procedures and complications. Multiple logistic regression analysis was performed, which estimated the Ods Ratio (OR) and respective confidence intervals (CI). Results chronic critical disease occurred in 150 patients (24.2%), of the 619 patients studied. The factors associated with CCD were organic dysfunction (OR=1.09) and gastrointestinal complications (OR=2.71). Patients with chronic critical disease, in addition to proseeding for surgical procedures, developed organic dysfunctions in different systems, presenting high scores in prognostic indexes, i.e., a worse prognosis, in addition to developing complications. Conclusion the identification of gastrointestinal complications and the increase in organic dysfunction as factors associated with chronic critical patients become useful to compose the clinical profile of patients and to plan intensive care for the traumatized patients, thus contributing to the prevention and management of these patients by nurses.

RESUMEN Objetivo identificar la prevalencia de enfermedad crítica crónica y factores asociados en pacientes hospitalizados por trauma en la Unidad de Cuidados Intensivos. Método estudio de casos y controles, con datos de las historias clínicas de adultos internados por trauma en una Unidad de Cuidados Intensivos, entre 2013 y 2019. Los datos fueron recolectados del libro de ingreso de pacientes, la historia clínica electrónica y los formularios del Servicio de Control de Infecciones Hospitalarias. . La variable dependiente fue la ocurrencia de enfermedad crítica crónica, y las variables independientes se relacionaron con características sociodemográficas, comorbilidades, traumatismos, atención prehospitalaria, índices pronósticos, procedimientos y complicaciones. Se realizó análisis de regresión logística múltiple, que estimó el Ods Ratio (OR) y los respectivos intervalos de confianza (IC). Resultados la enfermedad crítica crónica se presentó en 150 pacientes (24,2%), de los 619 estudiados. Los factores asociados a CC fueron disfunción orgánica (OR=1,09) y complicaciones gastrointestinales (OR=2,71). Los pacientes con enfermedad crítica crónica, además de requerir procedimientos quirúrgicos, desarrollaron disfunciones de órganos en diferentes sistemas, presentando puntuaciones altas en los índices pronósticos, o sea, peor pronóstico, además de desarrollar complicaciones. Conclusión La identificación de las complicaciones gastrointestinales y el aumento de la disfunción orgánica como factores asociados a los pacientes críticos crónicos se vuelven útiles para componer el perfil clínico de los pacientes y planificar la terapia intensiva para pacientes traumatizados, contribuyendo así a la prevención y manejo de estas condiciones. pacientes por la enfermera.

RESUMO Objetivo identificar a prevalência de doença crítica crônica e fatores associados em pacientes hospitalizados por trauma em Unidade de Terapia Intensiva. Método estudo de caso-controle, com dados de prontuários de adultos hospitalizados por trauma em uma Unidade de Terapia Intensiva, entre 2013 e 2019. Os dados foram coletados do livro de admissão de pacientes, do prontuário eletrônico e das fichas do Serviço de Controle de Infecção Hospitalar. A variável dependente foi a ocorrência de doença crítica crônica e as variáveis independentes relacionavam-se às características sociodemográficas, comorbidades, trauma, atendimento pré-hospitalar, índices prognósticos, procedimentos e complicações. Realizou-se análise de regressão logística múltipla, que estimou o Ods Ratio (OR) e respectivos intervalos de confiança (IC). Resultados a doença crítica crônica ocorreu em 150 pacientes (24,2%), dos 619 estudados. Os fatores associados à DCC foram disfunção orgânica (OR=1,09) e complicações gastrointestinais (OR=2,71). Os pacientes com doença crítica crônica, além de demandarem por procedimentos cirúrgicos, desenvolveram disfunções orgânicas em diferentes sistemas, apresentando altas pontuações nos índices de prognósticos, ou seja, um pior prognóstico, além de desenvolverem complicações. Conclusão a identificação das complicações gastrointestinais e o aumento da disfunção orgânica como fatores associados ao paciente crítico crônico tornam-se úteis para compor perfil clínico de pacientes e para planejar a assistência intensiva ao traumatizado, contribuindo, assim, para a prevenção e o manejo desses pacientes pelo enfermeiro.

Evaluation of pharmaceutical care in Brazilian primary health services settings: expanding objects and approaches

Abstract The objective of this work is to reflect on the objects and approaches usually employed in the evaluation of pharmaceutical care and their potential applicability in primary care settings. We conducted the review of the literature, and, to exemplify the advantages of expanding these objects and approaches, a real-world problem situation was selected: morbidity and mortality related to lack of treatment adherence by hypertensive patients in Brazilian primary health care services. Our reflections highlight the need to evaluate the effects of interventions, understood within Donabedian's normative model as 'outcomes,' which can be clinical, humanistic, or economic. Our findings show that most published studies, even those that set out to report outcomes, actually evaluate processes, such as number of visits, number of problems identified, types of problems, or acts of the practice performed by pharmacists. On the other hand, we also identify a need for study designs and indicators to enable 'finer' normative assessment. We also discuss the importance of shifting research toward an evaluative paradigm to allow strategic, logic, effects, production, efficiency, and implementation analyses. Finally, we suggest some possible indicators to evaluate pharmaceutical care interventions in the selected problem situation, through an extension of the objects and approaches proposed.

Longitudinalidade do cuidado: fatores associados à adesão à consulta puerperal segundo dados do PMAQ-AB / Longitudinal care: factors associated with adherence to postpartum follow-up according to data from PMAQ-AB / Longitudinalidad del cuidado: factores asociados a la adhesión de la consulta posparto según datos del PMAQ-AB

Objetivou-se identificar os fatores de longitudinalidade do cuidado associados à adesão das mulheres à consulta puerperal no Brasil. Trata-se de um estudo transversal com dados secundários de 19.177 puérperas que participaram da avaliação externa do terceiro ciclo do Programa Nacional de Melhoria do Acesso e da Qualidade da Atenção Básica (PMAQ-AB), de 2017. A variável dependente foi a realização de consulta puerperal e as variáveis independentes, agrupadas em níveis de maneira hierarquizada, foram as sociodemográficas e econômicas, como nível distal; e questões análogas à longitudinalidade do cuidado, como o nível proximal. Realizou-se análise de regressão logística múltipla, com entrada hierarquizada das variáveis, sendo as variáveis sociodemográficas e econômicas utilizadas para ajuste do modelo. Os resultados mostraram que a proporção de mulheres que realizaram consulta puerperal foi de 53%. Mulheres que receberam visita domiciliar do agente comunitário de saúde (ACS) na primeira semana após o parto (OR = 4,81), com sete ou mais consultas de pré-natal (OR = 2,74), que procuraram atendimento na unidade de saúde em questão (OR = 1,21) e atendidas pelo mesmo(a) médico(a) (OR = 1,14) têm mais chance de aderir à consulta puerperal. Conclui-se que a proporção de realização da consulta puerperal é baixa (53%), e que a adesão das mulheres à consulta puerperal é maior quando recebem visita do ACS, são acompanhadas pelo(a) mesmo(a) médico(a), têm acompanhamento pré-natal e têm uma unidade de saúde como fonte regular de cuidado. A longitudinalidade do cuidado foi identificada como um atributo da atenção primária que deve ser fortalecido para aprimorar a atenção pós-parto.

The aim was to identify factors of longitudinal care associated with women´s adherence to postpartum consultation in Brazil. This was a cross-sectional study of data from 19,177 postpartum women who participated in the external assessment of the third cycle of the Brazilian National Program for Improvement of Access and Quality of Basic Care (PMAQ-AB), 2017. The dependent variable was postpartum consultation, and the independent variables, grouped hierarchically, were sociodemographic and economic at the distal level and issues analogous to longitudinal care at the proximal level. Multiple logistic regression analysis was performed with hierarchical entry of variables, where sociodemographic and economic variables were used to adjust the model. The results showed that 53% of women had undergone postpartum follow-up. The odds of adherence to postpartum follow-up were higher in women who received a home visit by a community health agents in the first week after childbirth (OR = 4.81), those with seven or more prenatal consultations (OR = 2.74), those who had sought care at the health unit in question (OR = 1.21), and those who had been seen by the same physician (OR = 1.14). In conclusion, the proportion of postpartum consultations was low (53%), and adherence to postpartum follow-up was higher when women received visits by community health agents, were accompanied by the same physician, had regular prenatal care, and had a specific healthcare unit as their regular source of care. Consistent longitudinal care was identified as an attribute of primary care that should be strengthened to improve postpartum care.

El objetivo fue identificar factores de longitudinalidad del cuidado asociados a la adhesión de las mujeres a la consulta posparto en Brasil. Se trata de un estudio transversal con datos secundarios de 19.177 puérperas que participaron en la evaluación externa del tercer ciclo del Programa Nacional de Mejoría de Acceso y Calidad de la Atención Básica (PMAQ-AB), 2017. La variable dependiente fue la realización de la consulta posparto y las variables independientes, agrupadas en niveles de manera jerarquizada, fueron las sociodemográficas y económicas, como nivel distal; cuestiones análogas a la longitudinalidad del cuidado, como nivel proximal. Se realizó un análisis de regresión logística múltiple, con entrada jerarquizada de las variables, siendo las variables sociodemográficas y económicas utilizadas para el ajuste del modelo. Los resultados mostraron que la proporción de mujeres que realizaron la consulta posparto fue de un 53%. Las mujeres que recibieron visita domiciliaria del agentes comunitarios de salud durante la primera semana tras el parto (OR = 4,81), con siete o más consultas prenatales (OR = 2,74), buscaron atención en la unidad de salud en cuestión (OR = 1,21) y fueron atendidas por el mismo(a) médico(a) (OR = 1,14) tienen más oportunidades de adherirse a la consulta posparto. Se concluye que la proporción de realización de la consulta posparto es baja (53%), y que la adhesión de las mujeres a la consulta puerperal es mayor cuando reciben visita del agentes comunitarios de salud, están acompañadas por el(a) mismo(a) médico(a), hay seguimiento prenatal y hay una unidad de salud como fuente de cuidado regular. La longitudinalidad del cuidado se identificó como un atributo de la atención primaria que debe ser fortalecido para perfeccionar la atención posparto.